Harmonize

A proprietary active complex that addresses the root causes of adult acne, including oil that is both overproduced and sticky, bacterial imbalance, and inflammation. Published clinical data shows visible reduction in pore size and pore count after six weeks.

Decades of clinical evidence for acne, redness, and dark spots. Calms breakouts, eases irritation, and fades the marks they leave behind, all without being harsh. Largely responsible for the glow this serum is known for.

Regulates oil, refines the appearance of pores, and reduces redness, working alongside Azelaic Acid to calm and balance the skin.

A polyhydroxy acid that gently refines texture and reinforces the barrier, the rare exfoliating ingredient that leaves the skin feeling better, not more sensitive.

The humectants that draw moisture into the skin and keep it there, so the actives can work without leaving skin dry or tight.

Water (Aqua), Ethoxydiglycol, Pentylene Glycol, Caprylic/Capric Triglyceride, Azelaic Acid, Dimethyl Isosorbide, Niacinamide, Glycerin, Polyacrylate Crosspolymer-6, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Gluconolactone, Tocopheryl Acetate, Ethyl Linoleate, Hexylresorcinol, Arginine, Sodium Benzoate, Calcium Gluconate, Phenoxyethanol, Ethylhexylglycerin.

Harmonize is your nightly corrective. Every evening, cleanse, then apply 12 sprays of Calm Down Toner. If Defy Retinol Serum is part of your routine, apply it next and allow it to absorb. Then smooth one pump of Harmonize over the face, avoiding the eye area, and give it one minute before following with Skin Quencher Gel and your moisturizer. If our skincare professionals have recommended Acne Eraser, it is always the last step: a thin layer on active breakouts and the areas you are prone to.

Harmonize is formulated as your nightly corrective, so we recommend using it in the evening only. Your morning routine stays as it is. If Clarifying Serum is part of it, it works through the day while Harmonize works overnight.

Many people notice their skin feels more hydrated and comfortable within the first few days, along with a healthy glow. Visible improvements in breakouts, redness and overall clarity usually begin within a few weeks and keep improving over time. As with any acne treatment, consistency is key. So give Harmonize six weeks of consistent, nightly use, and be patient through the first couple of weeks while your skin adjusts.

No, and most people notice the opposite. Harmonize pairs its actives with Glycerin and Pentylene Glycol, humectants that draw moisture into the skin and hold it there, so treatment never comes at the cost of comfort. In a 4-week consumer perception study, 73% noticed smoother texture and less dryness.*

*Results from a 4-week consumer perception study of Emme Diane clients with active acne (22 completed). Self-reported. Individual results vary.

Yes. Harmonize was designed to be calming and barrier-supportive, especially for skin that has reacted to acne treatments in the past. In a 4-week consumer perception study, 82% experienced zero irritation. The rest reported only mild irritation, and none reported moderate or severe.* A mild, temporary tingle in active areas is normal as the formula gets to work. If your skin is particularly sensitive, begin every other evening for the first one to two weeks, then move to nightly.

Yes. Even oily skin needs hydration. And with acne, the amount of oil is only half the story. Acne-prone skin tends to produce oil that is thick and sticky, which clogs the pores. Harmonize addresses both: Niacinamide helps regulate how much oil skin produces, and the Skin Clarity Complex helps that oil flow instead of sticking, while lightweight humectants keep skin hydrated without heaviness. The result is skin that feels balanced, neither stripped nor greasy.

Yes. This is exactly who we formulated it for. Many acne treatments clear breakouts at the expense of skin health, leaving skin dry, irritated and more vulnerable to the visible signs of aging. Harmonize addresses the drivers of acne while maintaining hydration, calming the skin and supporting the barrier. That makes it a strong foundation for routines that also include age-defying formulas like Defy, because healthy skin is the starting point for both lasting clarity and visible correction.

Harmonize was never designed to be another azelaic acid serum. Azelaic Acid plays a supporting role, and it is largely responsible for the glow, but the hero is our proprietary Skin Clarity Complex, chosen to address several drivers of acne at once, including excess oil, bacterial imbalance and inflammation. Paired with Azelaic Acid, Niacinamide and barrier-supportive humectants, Harmonize works as a system rather than relying on a single active. Acne isn't one problem. So we didn't use one active ingredient.

Because your skin is being supported, not stripped. Traditional acne treatments often leave skin dehydrated and inflamed, which can make it look dull. Harmonize maintains hydration and calms the skin while it treats, and Azelaic Acid is largely responsible for the glow. We never asked our study participants about glow. They kept bringing it up anyway.

No. It changes how you use it. If our skincare professionals recommended Acne Eraser, keep it as the final step of your evening routine. Benzoyl peroxide is one of the most effective ingredients for quickly reducing acne-causing bacteria, which makes it an important tool while you gain control of active breakouts.

Harmonize treats the whole face without drying it out, so over time Acne Eraser can focus where it counts: a thin layer on active breakouts, flare-ups and the areas you are prone to. The goal is not to eliminate benzoyl peroxide. It is to help your skin rely on it less.

Yes. The two do different, complementary jobs. 

Clarifying Serum works inside the pore. It gently clears the dead skin cells and buildup that become trapped and lead to congestion, encouraging healthy cell turnover and smoother texture.

Harmonize works on the environment around the pore. It addresses excess oil, bacterial imbalance and inflammation, calms redness and supports the barrier while treating active breakouts.

Clarifying Serum addresses what clogs the pore. Harmonize addresses what allows acne to persist. Use Clarifying Serum in the morning and Harmonize at night: one clears the pathway, and the other helps create the conditions for lasting clarity.

Yes, and they work well together. Defy helps increase cell turnover, smooth texture, refine the look of pores and improve the appearance of fine lines and discoloration. Harmonize calms inflammation, addresses the drivers of acne and supports overall balance.

In the evening, Defy goes on after Calm Down Toner. Give it about one minute to absorb, then apply Harmonize and continue with Skin Quencher Gel and your moisturizer. If your skin feels sensitive, alternate nights or reach out to our skincare professionals.

In most cases, yes, though you may find you need fewer of them. Harmonize combines several corrective and supportive ingredients in one step, and alongside Clarifying Serum it is designed to be your primary acne treatment. Keep the rest of your routine consistent while you introduce Harmonize, then simplify over time based on how your skin responds. If you are unsure how to layer, our skincare professionals are happy to help.

Yes. Harmonize can be used on other acne-prone areas, such as the chest, back and shoulders.